Quote from report:  “Based on their analyses, the team posits that bradykinin — the compound that dilates blood vessels and makes them permeable — is overproduced in the body of COVID-19 patients; related systems either contribute to overproduction or cannot slow the process. Excessive bradykinin leads to leaky blood vessels, allowing fluid to build up in the body’s soft tissues.”

In a similar fashion another quote from the report:  Researchers found an increased expression of enzymes that can trigger the production of bradykinin and a decreased expression of enzymes that would break down bradykinin — the perfect storm. The team also uncovered that an enzyme that forestalls the bradykinin cascade — the angiotensin-converting enzyme, known as ACE — was less expressed in COVID-19 patients. At least ten existing drugs are known to act on the specific pathways Jacobson’s team studied, but large-scale clinical trials are needed to determine whether they might be effective at treating COVID-19.

Means simply the virus causes the body to produce more bradykinin which causes blood vessels to expand and leak fluid out of the blood vessels.  All over the body, everywhere.  The body produces an enzyme to balance the fluid in the body but the virus causes this enzyme to not be produced so no slow down occurs.  We need a drug to produce more of this enzyme.  Or simply use the enzyme itself as a drug to increase its quantity in the body and its effect thereof.

And finally another quote:  The lungs of COVID-19 patients are known to have an increased amount of hyaluronic acid, a gooey substance found in connective tissues that can trap around 1,000 times its own weight in water to form a hydrogel. The team also found that genes in the cells of COVID-19 patients increased the production of the substance and decreased its breakdown. The findings suggest that further experimental study of drug compounds known to slow the synthesis of hyaluronic acid and the mechanisms involved in the process is warranted.

Means simply another drug to the rescue.  Hope they can do it soon.